To set or change a signature in G Suite, first log into the user's account at https://mail.google.com/mail/

Once logged in, click on the flower/cog button in the top-right corner and choose settings from the presented menu. This exposes all of the settings and controls for the user's account, collected together under relevant tabs.

On the General tab, about two-thirds down the page, are the boxes that control the signature, and the [Save] button is at the bottom of this page to commit any changes made.

Where an account is configured with more than one reply address, a separate signature can be configured per address using the drop-down menu. The changes per signature will be saved as each is edited but the whole will only be committed if the [Save] button at the bottom of the page is clicked.